How splicing confers treatment resistance in prostate cancer

How splicing confers treatment resistance in prostate cancer

A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.

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Bibliographische Detailangaben
Veröffentlicht in:eLife 2022-08, Vol.11
Hauptverfasser: Konda, Prathyusha, Viswanathan, Srinivas R
Format: Artikel
Sprache:eng
Schlagworte:
Androgen Receptor
AR-V7
Cancer
Cancer Biology
Care and treatment
Drug therapy
Genetic transcription
Insight
intranuclear mobility
nuclear import
Prostate cancer
Testosterone
transcriptional activity
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Beschreibung
Zusammenfassung:A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.82070