Diabetes and tuberculosis syndemic in India: A narrative review of facts, gaps in care and challenges

Both diabetes mellitus (DM) and tuberculosis (TB) are prevalent all across in India. TB‐DM comorbidity has emerged as a syndemic and needs more attention in India considering gaps in screening, clinical care, and research. This paper is intended to review published literature on TB and DM in India to understand the burden of the dual epidemic and its trajectory and to obtain perspectives on the gaps, constraints, and challenges in care and treatment of this dual epidemic. A literature search was carried out on PubMed, Scopus, and Google Scholar, using the key words ‘Tuberculosis’ OR ‘TB’ AND ‘Diabetes’ OR ‘Diabetes Mellitus’ AND ‘India’, focusing on the research published between the year 2000 to 2022. The prevalence of DM is high in patients with TB. Quantitative data on the epidemiological situation of TB/DM in India such as incidence, prevalence, mortality, and management are lacking. During the last 2 years convergence of TB‐DM syndemic with the COVID‐19 pandemic has increased cases with uncontrolled DM but also made coordinated control of TB‐DM operationally difficult and of low effectiveness. Research regarding TB‐DM comorbidity is required in the context of epidemiology and management. Detection and bidirectional screening are aggressively warranted. Management of DM in those with TB‐DM comorbidity needs more efforts, including training and supervision of frontline workers. Highlights Some data suggest that coexistence of diabetes mellitus and tuberculosis substantially increases the failure of treatment of antituberculosis drugs. The COVID‐19 pandemic has severely affected the healthcare delivery of tuberculosis‐diabetes mellitus patients. The tuberculosis‐diabetes mellitus syndemic needs a more aggressive focus to have a better outcome.