Current nanocarriers in therapeutic improvement of Andrographolide

Currently, herbs have been investigated for novel bioactivities and improvement of traditional therapeutic effectiveness. Among them, Andrographis paniculata, with the active component Andrographolide, is well recognized as an anti-inflammatory, anti-bacterial, anti-cancer, anti-hypertensive, anti-hyperglycaemic, hepatoprotective, and anti-hyperlipidaemic compound. However, Andrographolide has poor physicochemical properties that limit its medical application. In this review article, nano drug delivery systems including nanovesicles, inorganic nanoparticles, lipid-based nanoparticles, polymeric nanoparticles, nanocrystals, nanoemulsions, and microemulsions, which can deliver Andrographolide through different routes such as oral, injection, or dermal, and their influences in increasing treatment benefits are presented.