MiR-145 is involved in the proliferation of bovine mammary epithelial cells and regulates bovine insulin receptor substrate 1

MiR-145 is involved in the proliferation of bovine mammary epithelial cells and regulates bovine insulin receptor substrate 1

MicroRNAs (miRNAs) are short noncoding RNAs that can regulate target gene expression at the posttranscriptional level. It has been reported that bta-miR-145 shows differential expression between the different lactation stages of bovine mammary glands, but the function of bta-miR-145 in normal mammar...

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Veröffentlicht in:Italian journal of animal science 2020-12, Vol.19 (1), p.536-543
Hauptverfasser: Li, Wenqing, Li, Chenwan, Lu, Jinghui, Zhao, Yangning
Format: Artikel
Sprache:eng
Schlagworte:
Binding sites
bta-miR-145
Cell growth
Cell proliferation
Epithelial cells
Gene expression
Insulin
Insulin receptor substrate 1
IRS1
Lactation
Mammary gland
MAP kinase
MicroRNAs
miRNA
Post-transcription
primary bovine mammary epithelial cell
Signal transduction
Transfection
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Zusammenfassung:MicroRNAs (miRNAs) are short noncoding RNAs that can regulate target gene expression at the posttranscriptional level. It has been reported that bta-miR-145 shows differential expression between the different lactation stages of bovine mammary glands, but the function of bta-miR-145 in normal mammary glands remains unknown. The overexpression of bta-miR-145 significantly decreased the proliferation of mammary epithelial cells (p 
ISSN:1828-051X
1594-4077
1828-051X
DOI:10.1080/1828051X.2020.1732234