Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditio...

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Veröffentlicht in:International journal of molecular sciences 2020-08, Vol.21 (17), p.6009
Hauptverfasser: Gelfo, Valerio, Romaniello, Donatella, Mazzeschi, Martina, Sgarzi, Michela, Grilli, Giada, Morselli, Alessandra, Manzan, Beatrice, Rihawi, Karim, Lauriola, Mattia
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Sprache:eng
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Zusammenfassung:IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-inflammatory activity. Beyond its biological role as a regulator of the innate immune response, IL-1 is involved in stress and chronic inflammation, therefore it is responsible for several pathological conditions. In particular, IL-1 is known to exert a critical function in malignancies, influencing the tumor microenvironment and promoting cancer initiation and progression. Thus, it orchestrates immunosuppression recruiting pro-tumor immune cells of myeloid origin. Furthermore, new recent findings showed that this cytokine can be directly produced by tumor cells in a positive feedback loop and contributes to the failure of targeted therapy. Activation of anti-apoptotic signaling pathways and senescence are some of the mechanisms recently proposed, but the role of IL-1 in tumor cells refractory to standard therapies needs to be further investigated.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21176009