Biomembrane simulations: Computational studies of biological membranes

Biological membranes (short: biomembranes) are one of the most complex structures that allow life to exist. They play an important role not only as an effective structural barrier separating and protecting an internal environment from an external environment, but also provide an area of significant biological activities made possible with the help of various functional macromolecules, including phospholipids, cholesterol, proteins, and carbohydrates. In recent years, computer simulations have become popular (and complement laboratory experiments) to explore the intricate interplay between these molecules over spatial and time scales. This article provides information about the characteristics of biomembranes and reviews recent advances in computational studies as is described in the book on biomembrane simulations by Max L. Berkowitz. •This article is about the theoretical and practical aspects of modeling to understand the structure, role, and functioning of biological membranes.•The article is based on and includes data described in the book entitled “Biomembrane Simulations: Computational Studies of Biological Membranes,” edited by Max L. Berkowitz.•The article emphasizes the value of mathematical modeling and simulation approaches to study biomembranes at biologically relevant high spatial and high temporal resolution.