Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications

Aim. То assess endothelial function (EF) and lipid peroxidation (LPO) in patients with arterial hypertension (AH) and its cerebral complications.Material and methods. In total, 49 patients with ischemic stroke (IS), 37 patients with uncomplicated essentialAH (EAH) and 25 blood donors as controls were examined. NO concentration (its stable metabolites, nitrates and nitrites) was measured by Griss method; citrulline (C) and malonic dialdehyde (MDA) levels were assessed with photocolorimetric method. Desquamated endotheliocytes (DE) were counted according to the method by J. Hladovec. LPO and plasma antioxidant activity (AOA) were studied with biochemiluminescence analysis.Results. In IS patients, NO and C concentrations were lowerthan inAH patients and controls, while DE numbers were higher in the former. These parameters were combined into one factor, “integral index of endothelial dysfunction” (IIED), with values of -0,86±0,19, 0,12±0,09, and 1,21±0,23 units in patients with IS, AH and in controls, respectively (p