Comparison of a single intravenous infusion of alfentanil or sufentanil combined with target-controlled infusion of propofol for daytime hysteroscopy: a randomized clinical trial

Plain language summary Alfentanil combined with propofol is safer and more suitable for daytime hysteroscopy Why was the study done? Hysteroscopy is a procedure to look inside the uterus, and managing pain and safety is crucial. The study was conducted to compare the safety and effectiveness of two pain relief medications, alfentanil and sufentanil, used during daytime hysteroscopy. What did the researchers do? We included 160 patients scheduled for daytime hysteroscopy. And we divided these patients into two groups: Group A: Received a single injection of 10 μg/kg of alfentanil. Group S: Received a single injection of 0.15 μg/kg of sufentanil. Both groups were also given propofol, a sedative, during the procedure. What did the researchers find? Group A (alfentanil): Fewer patients experienced low oxygen levels (hypoxemia) and postoperative nausea and vomiting. They also had more stable blood pressure and heart rate. Group S (sufentanil): More patients experienced hypoxemia and postoperative nausea and vomiting. What do the findings mean? The findings suggest that alfentanil at 10 μg/kg is safer and just as effective for pain relief during daytime hysteroscopy compared to sufentanil at 0.15 μg/kg. It leads to fewer breathing problems and other side effects, making it a better option for patients undergoing this procedure.