Hemostasis functions are associated with hemorrhagic transformation in non-atrial fibrillation patients: a case-control study

Hemorrhagic transformation (HT) is a serious neurological complication of acute ischemic stroke (AIS) after revascularization. The majority of AIS patients do not have atrial fibrillation (AF) which could also develop into HT. In this study, we aimed to explore whether hemostasis parameters are risk...

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Veröffentlicht in:BMC neurology 2021-01, Vol.21 (1), p.36-36, Article 36
Hauptverfasser: Cheng, Hao-Ran, Chen, Yun-Bin, Zeng, Ya-Ying, Ruan, Yi-Ting, Yuan, Cheng-Xiang, Cheng, Qian-Qian, Chen, Hui-Jun, Luan, Xiao-Qian, Huang, Gui-Qian, He, Jin-Cai
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Sprache:eng
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Zusammenfassung:Hemorrhagic transformation (HT) is a serious neurological complication of acute ischemic stroke (AIS) after revascularization. The majority of AIS patients do not have atrial fibrillation (AF) which could also develop into HT. In this study, we aimed to explore whether hemostasis parameters are risk factors of HT in non-AF patients. We consecutively enrolled 285 AIS patients with HT. Meanwhile, age- and sex-matched 285 AIS patients without HT were included. The diagnosis of HT was determined by brain CT or MRI during hospitalization. All patients were divided into two subgroups based on the presence of AF and explore the differences between the two subgroups. Blood samples were obtained within 24 h of admission, and all patients were evenly classified into three tertiles according to platelet counts (PLT) levels. In this study, we found the first PLT tertile (OR = 3.509, 95%CI = 1.268-9.711, P = 0.016) was independently associated with HT in non-AF patients, taking the third tertile as a reference. Meanwhile, we also found mean platelet volume (MPV) (OR = 0.605, 95%CI = 0.455-0.805, P = 0.001) and fibrinogen (FIB) (OR = 1.928, 95%CI = 1.346-2.760, P
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-021-02065-3