Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans

Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans

The U.S. suicide mortality rate has steadily increased during the past two decades, particularly among military veterans; however, the epigenetic basis of suicidal thoughts and behaviors (STB) remains largely unknown. To address this issue, we conducted an epigenome-wide association study of DNA met...

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Veröffentlicht in:Frontiers in psychiatry 2023-05, Vol.14, p.1145375-1145375
Hauptverfasser: Kimbrel, Nathan A, Garrett, Melanie E, Evans, Mariah K, Mellows, Clara, Dennis, Michelle F, Hair, Lauren P, Hauser, Michael A, Ashley-Koch, Allison E, Beckham, Jean C
Format: Artikel
Sprache:eng
Schlagworte:
epigenetics
methylation
Psychiatry
suicidal ideation
suicide
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Zusammenfassung:The U.S. suicide mortality rate has steadily increased during the past two decades, particularly among military veterans; however, the epigenetic basis of suicidal thoughts and behaviors (STB) remains largely unknown. To address this issue, we conducted an epigenome-wide association study of DNA methylation (DNAm) of peripheral blood samples obtained from 2,712 U.S. military veterans. Three DNAm probes were significantly associated with suicide attempts, surpassing the multiple testing threshold (FDR -value
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2023.1145375