Systemic effector and regulatory immune responses to chlamydial antigens in trachomatous trichiasis

Trachomatous trichiasis (TT) caused by repeated or chronic ocular infection with Chlamydia trachomatis is the result of a pro-fibrotic ocular immune response. At the conjunctiva, the increased expression of both inflammatory (IL1B, TNF) and regulatory cytokines (IL10) have been associated with adver...

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Veröffentlicht in:Frontiers in cellular and infection microbiology 2011-01, Vol.2, p.10-10
Hauptverfasser: Gall, Alevtina, Horowitz, Amir, Joof, Hassan, Natividad, Angels, Tetteh, Kevin, Riley, Eleanor, Bailey, Robin L, Mabey, David C W, Holland, Martin J
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Sprache:eng
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Zusammenfassung:Trachomatous trichiasis (TT) caused by repeated or chronic ocular infection with Chlamydia trachomatis is the result of a pro-fibrotic ocular immune response. At the conjunctiva, the increased expression of both inflammatory (IL1B, TNF) and regulatory cytokines (IL10) have been associated with adverse clinical outcomes. We measured in vitro immune responses of peripheral blood to a number of chlamydial antigens. Peripheral blood effector cells (CD4, CD69, IFNγ, IL-10) and regulatory cells (CD4, CD25, FOXP3, CTLA4/GITR) were readily stimulated by C. trachomatis antigens but neither the magnitude (frequency or stimulation index) or the breadth and amount of cytokines produced in vitro [IL-5, IL-10, IL-12 (p70), IL-13, IFNγ, and TNFα] were significantly different between TT cases and their non-diseased controls. Interestingly we observed that CD4+ T cells account for
ISSN:1664-302X
1664-302X
2235-2988
DOI:10.3389/fmicb.2011.00010