Dissecting the mammary gland one cell at a time

Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing...

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Veröffentlicht in:	Nature communications 2018-06, Vol.9 (1), p.2473-3, Article 2473
Hauptverfasser:	Cristea, Simona, Polyak, Kornelia
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/532 Animals Breastfeeding & lactation Cell Differentiation Cell Lineage Cell Transformation, Neoplastic Comment Data analysis Developmental stages Differentiation (biology) Epithelial Cells - cytology Epithelium Female Gene expression Gene Expression Regulation, Developmental Hierarchies Hormones Humanities and Social Sciences Humans Mammary gland Mammary Glands, Animal - cytology Mammary Glands, Animal - growth & development Mammary Glands, Animal - metabolism Mammary Glands, Human - cytology Mammary Glands, Human - growth & development Mammary Glands, Human - metabolism Mice Models, Biological multidisciplinary Ovaries Population Pregnancy Puberty Ribonucleic acid RNA Science Science (multidisciplinary) Sequence Analysis, RNA Stem cells Stem Cells - cytology Stem Cells - metabolism Tumorigenesis
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Beschreibung
Zusammenfassung:	Dissecting cellular differentiation hierarchies in the mammary gland is a prerequisite for understanding both normal development and malignant transformation during tumorigenesis and tumor cell-of-origin. To achieve these goals, several recent papers utilized single cell RNA-seq and lineage tracing to improve our understanding of the composition of the mammary epithelium at different developmental stages.
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-018-04905-2