Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths

We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity...

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Veröffentlicht in:	Emerging infectious diseases 2022-01, Vol.28 (1), p.244-247
Hauptverfasser:	Heinrich, Fabian, Schröder, Ann Sophie, Gerberding, Anna-Lina, Gerling, Moritz, Langenwalder, Felicia, Lange, Philine, Heinemann, Axel, Bibiza-Freiwald, Eric, Nörz, Dominik Sebastian, Aepfelbacher, Martin, Pfefferle, Susanne, Ondruschka, Benjamin, Lütgehetmann, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Ag-RDT Antibodies antigen-detecting rapid diagnostic test Antigens Autopsy coronavirus disease 2019 Coronaviruses COVID-19 COVID-19 diagnostic tests Diagnostic Tests, Routine Humans Immune system Infections infectivity Legal medicine Medicine Methods Original Research Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2–Associated Deaths Research Letter SARS-CoV-2 Sensitivity and Specificity Severe acute respiratory syndrome coronavirus 2 Testing Viral Load
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Zusammenfassung:	We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.
ISSN:	1080-6040 1080-6059 1080-6059
DOI:	10.3201/eid2801.211749