SPONTANEOUS PROLIFERATIVE ACTIVITY OF B1LYMPHOCYTES IN RHEUMATOID ARTHRITIS, SYSTEMIC LUPUS ERYTHEMATOSUS AND NON1SPECIFIC ULCERATIVE COLITIS

The aim of present work was to study spontaneous proliferative activity of B-lymphocytes (SP-ABL) in the patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and non-specific ulcerative colitis (NSUC). In total, 128 patients with RA, 52 patients with SLE, and 29 patients with NSUC were observed. Thirty-four patients with osteoarthrosis (OA), 27 patients with reactive arthritis (ReA), 28 patients with chronic hepatitis (CH), 19 patients with chronic colitis (ChC), and 30 healthy donors comprised the control group. Significantly higher mean levels of SPABL have been revealed in the patients with RA, SLE, and NSUC, as compared to the control group. The SPABL values proved to exceed normal limits in 90.3 % of SLE patients, 82.8 % patients with RA, in 79.3 % patients with NSUC, and in 88.9 % of RA group with liver affection. Determination of SPABL may be used for assessment of immunologic activity in autoimmune inflammatory diseases.