Role of serial urine sediment examination in progression and outcome of sepsis-associated acute kidney injury

Introduction Sepsis-associated acute kidney injury (SA-AKI) is common in hospitalized patients. There is a rising interest in validating new tools for predicting its prognosis and outcome. We aimed to assess the role of serial urine sediment examination in the progression and outcome of SA-AKI.Material and Methods This research is a prospective study which included 80 patients with SA-AKI stage 1 or 2. Urine sediment examination was done with calculations of Perazella score (PS) and Chawla score (CS) at days 1, 3, and 7 and correlated with AKI progression and outcomes.Results Fifty-eight females and 22 males were enrolled in the study with a mean age of 61.10 ± 11.26 years, and initial serum creatinine at presentation was 2.06 ± 0.51 mg/dl.47.5% of patients progressed to stage 3 AKI, while 52.5% did not progress. Patients who progressed to stage 3 AKI had a significantly lower urine output at presentation, higher need for dialysis, higher mortality, higher serum creatinine, and lower eGFR at discharge and after 3 months. Both PS and CS at the time of diagnosis (day 1) showed no statistical difference between those with and without AKI progression. However, examination at day 3 and 7 revealed that AKI progressors had significantly higher PS and CS (p