Research advances in the roles of local anesthetics in tumor metastasis and recurrence

Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer. Perioperative applications of local anesthetics can not only reduce the amount of opioids, but also inhibit tumor metastasis and recurrence by blocking sodium channels of cancer cells, changing epigenetics, decreasing inflammation and improving immune function. The exploration of the mechanism of local anesthetics in tumor metastasis and recurrence provides the new strategies for the optimal use of local anesthetics in cancer patient's perioperatively chemotherapy.