The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets
N6-methyladenosinen (m A) methylation is a frequent RNA methylation modification that is regulated by three proteins: "writers", "erasers", and "readers". The m A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation...
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Veröffentlicht in: | Frontiers in oncology 2022-12, Vol.12, p.1074307-1074307 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | N6-methyladenosinen (m
A) methylation is a frequent RNA methylation modification that is regulated by three proteins: "writers", "erasers", and "readers". The m
A modification regulates RNA stability and other mechanisms, including translation, cleavage, and degradation. Interestingly, recent research has linked m
A RNA modification to the occurrence and development of cancers, such as hepatocellular carcinoma and non-small cell lung cancer. This review summarizes the regulatory role of m
A RNA modification in gastric cancer (GC), including targets, the mechanisms of action, and the potential signaling pathways. Our present findings can facilitate our understanding of the significance of m
A RNA modification in GC. |
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ISSN: | 2234-943X 2234-943X |
DOI: | 10.3389/fonc.2022.1074307 |