When monoclonal gammopathy‐associated chronic neutrophilic leukemia is a reactive process distinct from a clonal myeloproliferative neoplasm: Lessons from mistakes

According to World Health Organization (WHO) classification, presence of a plasma cell disorders (PCDs) should be investigate to avoid CNL misdiagnosis. [...]serum G-CSF dosage could be the most powerful tool to make a prompt diagnosis of reactive neutrophilia to PCD which could have avoid, in our patient, inefficient therapy (as ruxolitinib), AHSCT morbidity, and donor-cell MDS. [...]this report describes a correlated response to BD between PB neutrophils, spleen size, monoclonal component, and serum G-CSF level.