Two spectrophotometric methods for simultaneous determination of some antihyperlipidemic drugs

Two simple, accurate, precise and economic spectrophotometric methods have been developed for simultaneous determination of Atorvastatin calcium (ATR) and Ezetimibe (EZ) in their bulk powder and pharmaceutical dosage form. Method (I) is based on dual wavelength analysis while method (II) is the mean...

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Veröffentlicht in:Journal of pharmaceutical analysis 2012-08, Vol.2 (4), p.279-284
Hauptverfasser: Abdelwahab, Nada S., El-Zeiny, Badr A., Tohamy, Salwa I.
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Sprache:eng
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Zusammenfassung:Two simple, accurate, precise and economic spectrophotometric methods have been developed for simultaneous determination of Atorvastatin calcium (ATR) and Ezetimibe (EZ) in their bulk powder and pharmaceutical dosage form. Method (I) is based on dual wavelength analysis while method (II) is the mean centering of ratio spectra spectrophotometric (MCR) method. In method (I), two wavelengths were selected for each drug in such a way that the difference in absorbance was zero for the second drug. At wavelengths...
ISSN:2095-1779
2214-0883
DOI:10.1016/j.jpha.2012.02.002