Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis

We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from datab...

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Veröffentlicht in:	BMC neurology 2019-11, Vol.19 (1), p.284-11, Article 284
Hauptverfasser:	Chai, Bingyan, Gao, Fulin, Wu, Ruipeng, Dong, Tong, Gu, Cheng, Lin, Qiaoran, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Algorithms Alzheimer Disease - blood Alzheimer's disease Anopheles Cross-Sectional Studies Database industry Databases, Factual Dementia Dementia - blood Humans International economic relations Meta-analysis Proportional Hazards Models Prospective Studies Risk Factors Vitamin D Vitamin D - blood Vitamin D deficiency Vitamin D Deficiency - complications Vitamins
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Beschreibung
Zusammenfassung:	We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (
ISSN:	1471-2377 1471-2377
DOI:	10.1186/s12883-019-1500-6