Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Roles of OLR1 and IL17A variants on clinical phenotypes of Turkish patients undergoing coronary artery bypass surgery

Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are invo...

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Veröffentlicht in:Türk biyokimya dergisi 2022-10, Vol.47 (5), p.571-579
Hauptverfasser: Recep, Eymen, Bayoglu, Burcu, Arslan, Caner, Goksedef, Deniz, Ipek, Gokhan
Format: Artikel
Sprache:eng
Schlagworte:
coronary artery disease
genetic variant
IL17A
OLR1
oxidative stress
rs11053646
rs3819025
rs8193037
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Zusammenfassung:Coronary artery disease (CAD) is a pathological condition resulting from atherosclerosis in the coronary arteries. IL17A has been shown to recruit and activate macrophages in atherosclerotic lesions, thereby participating in plaque destabilization. Currently, whether OLR1 and IL17A variants are involved in the pathogenesis of CAD is unclear. This case-control study aimed to investigate their roles in CAD etiology and prognosis.
ISSN:1303-829X
1303-829X
DOI:10.1515/tjb-2021-0214