A Significant Association between Type 1 Diabetes and Helicobacter pylori Infection: A Meta-Analysis Study

: Type 1 diabetes mellitus (T1DM) is a chronic and serious condition that is characterized by inadequate pancreatic-β-cells' insulin production. The connection between T1DM and infection remains uncertain. This study aimed to conduct a systematic meta-analysis to examine the association between infection, hemoglobin A1c levels, and the development of T1DM. : The initial search identified 451 articles on the association between infection and T1DM. Among them, 12 articles had 2797 participants who met the inclusion criteria for an advanced meta-analysis. : A significant association was observed between infection and T1DM (OR 1.77, 95% CI 1.47-2.12, < 0.0001), with heterogeneity: Tau = 0.47; Chi = 57.07, df = 11 ( < 0.0001); I = 81%. Subgroup analysis showed that infection was significantly associated with a longer duration of T1DM and higher hemoglobin A1c levels ( < 0.001 for both) but not with age at T1DM diagnosis ( = 0.306). These findings contribute to the understanding of the association between infection and T1DM and highlight the potential role of in influencing the duration and glycemic control of diabetes. Therefore, pediatric patients who have longstanding T1DM and poor glycemic control should be screened for infection.