Angiotensin II infusion in COVID-19-associated vasodilatory shock: a case series

[...]in this pandemic setting, the ethics of ensuring compassionate drug use to all patients were considered a priority. [...]before considering controlled trials, evidence of some physiological safety was considered important. [...]under the extraordinary pressures of the most dramatic health disas...

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Veröffentlicht in:	Critical care (London, England) England), 2020-05, Vol.24 (1), p.227-227, Article 227
Hauptverfasser:	Zangrillo, Alberto, Landoni, Giovanni, Beretta, Luigi, Morselli, Federica, Serpa Neto, Ary, Bellomo, Rinaldo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiotensin II Angiotensin II - therapeutic use Angiotensins Betacoronavirus Cohort Studies Coronavirus Infections - complications Coronavirus Infections - drug therapy Coronaviruses COVID-19 Critical care Diuretics Drug approval Enzymes Female Humans Infusions, Intravenous Italy Male Middle Aged Pandemics Physiology Pneumonia, Viral - complications Pneumonia, Viral - drug therapy Research Letter Respiration, Artificial SARS-CoV-2 Shock - drug therapy Shock - etiology Vasoconstrictor Agents - therapeutic use Vasodilation Vasodilator agents
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Zusammenfassung:	[...]in this pandemic setting, the ethics of ensuring compassionate drug use to all patients were considered a priority. [...]before considering controlled trials, evidence of some physiological safety was considered important. [...]under the extraordinary pressures of the most dramatic health disaster in Italy’s history in a century, this study was the best possible under the circumstances. [...]we provide the first observational cohort study of ANGII infusion in ventilated patients with COVID-19-associated vasodilatory shock.
ISSN:	1364-8535 1466-609X 1364-8535 1366-609X
DOI:	10.1186/s13054-020-02928-0