Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells
Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues wer...
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Veröffentlicht in: | Scientific reports 2022-07, Vol.12 (1), p.13131-17, Article 13131 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on LN-18 human glioblastoma cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC
50
values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC
50
of 31 µM. Moreover, a significant increase (
p
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-022-16274-4 |