Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells

Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues wer...

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Veröffentlicht in:Scientific reports 2022-07, Vol.12 (1), p.13131-17, Article 13131
Hauptverfasser: Razali, Nur Syahirah Che, Lam, Kok Wai, Rajab, Nor Fadilah, A. Jamal, A. Rahman, Kamaluddin, Nurul Farahana, Chan, Kok Meng
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Sprache:eng
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Zusammenfassung:Curcumin has demonstrated potential cytotoxicity across various cell lines despite its poor bioavailability and rapid metabolism. Therefore, our group have synthesized curcuminoid analogues with piperidone derivatives, FLDP-5 and FLDP-8 to overcome these limitations. In this study, the analogues were assessed on LN-18 human glioblastoma cells in comparison to curcumin. Results from cytotoxicity assessment showed that FLDP-5 and FLDP-8 curcuminoid analogues caused death in LN-18 cells in a concentration-dependent manner after 24-h treatment with much lower IC 50 values of 2.5 µM and 4 µM respectively, which were more potent compared to curcumin with IC 50 of 31 µM. Moreover, a significant increase ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-16274-4