Amoxycillin and Metronidazole Therapy for Helicobacter pylori Eradication: A 10-Year Trend in Turin, Italy

Helicobacter pylori (H. pylori) infection plays a crucial role in causing gastritis and peptic ulcer disease (PUD). To date, despite the several regimens proposed, no therapy leads to a 100% H. pylori eradication rate (1). As the antimicrobial activity of metronidazole is marginally affected by low pH, this drug may be highly effective against H. pylori. The European Helicobacter Study Group has advised to employ a metronidazole-based triple therapy as choice in treating H. pylori infection in relation to specific resistance rate in each region (2). Recently, a multicentric study revealed that, in Southern Europe, the primary rate of H. pylori metronidazole resistance was around 30% (3).