A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance

A Novel Class of tRNA-Derived Small Non-Coding RNAs Respond to Myocardial Hypertrophy and Contribute to Intergenerational Inheritance

tRNA-derived fragments (tRFs) are a new class of non-coding RNA that play an important role in regulating cellular RNA processing and protein translation. However, there is currently no study reporting the influence of tRFs on myocardial hypertrophy. In this study, we used an isoproterenol (ISO)-ind...

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Veröffentlicht in:Biomolecules (Basel, Switzerland) Switzerland), 2018-07, Vol.8 (3), p.54
Hauptverfasser: Shen, Linyuan, Gan, Mailin, Tan, Zhengdong, Jiang, Dongmei, Jiang, Yanzhi, Li, Mingzhou, Wang, Jinyong, Li, Xuewei, Zhang, Shunhua, Zhu, Li
Format: Artikel
Sprache:eng
Schlagworte:
Communication
intergenerational inheritance
myocardial hypertrophy
tRNA fragments
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Zusammenfassung:tRNA-derived fragments (tRFs) are a new class of non-coding RNA that play an important role in regulating cellular RNA processing and protein translation. However, there is currently no study reporting the influence of tRFs on myocardial hypertrophy. In this study, we used an isoproterenol (ISO)-induced myocardial hypertrophy rat model. Small RNA (
ISSN:2218-273X
2218-273X
DOI:10.3390/biom8030054