Evaluation of the metabolomic profile through 1H-NMR spectroscopy in ewes affected by postpartum hyperketonemia

Evaluation of the metabolomic profile through 1H-NMR spectroscopy in ewes affected by postpartum hyperketonemia

Ketosis is one of the most important health problems in dairy sheep. The aim of this study was to evaluate the metabolic alterations in hyperketonemic (HYK) ewes. Forty-six adult Sardinian ewes were enrolled between 7 ± 3 days post-partum. Blood samples were collected from the jugular vein using Ven...

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Veröffentlicht in:Scientific reports 2022-10, Vol.12 (1), p.16463-16463, Article 16463
Hauptverfasser: Lisuzzo, Anastasia, Laghi, Luca, Fiore, Filippo, Harvatine, Kevin, Mazzotta, Elisa, Faillace, Vanessa, Spissu, Nicoletta, Zhu, Chenglin, Moscati, Livia, Fiore, Enrico
Format: Artikel
Sprache:eng
Schlagworte:
631/601/1737
692/53/2421
Electron transport chain
Health problems
Humanities and Social Sciences
Inflammation
Jugular vein
Ketosis
Magnetic resonance spectroscopy
Metabolic pathways
Metabolism
Metabolites
Metabolomics
multidisciplinary
Nervous system
NMR
Nuclear magnetic resonance
Principal components analysis
Science
Science (multidisciplinary)
Tricarboxylic acid cycle
Urea
Variance analysis
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Zusammenfassung:Ketosis is one of the most important health problems in dairy sheep. The aim of this study was to evaluate the metabolic alterations in hyperketonemic (HYK) ewes. Forty-six adult Sardinian ewes were enrolled between 7 ± 3 days post-partum. Blood samples were collected from the jugular vein using Venosafe tubes containing clot activator from jugular vein after clinical examination. The concentration of β-hydroxybutyrate (BHB) was determined in serum and used to divide ewes into assign ewes into: Non-HYK (serum BHB 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-20371-9