Metformin ameliorates valve interstitial cell calcification by promoting autophagic flux

Calcific aortic valve disease (CAVD) is the most common heart disease of the developed world. It has previously been established that metformin administration reduces arterial calcification via autophagy; however, whether metformin directly regulates CAVD has yet to be elucidated. In the present stu...

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Veröffentlicht in:	Scientific reports 2023-12, Vol.13 (1), p.21435-21435, Article 21435
Hauptverfasser:	Phadwal, K., Tan, X., Koo, E., Zhu, D., MacRae, V. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337 631/80 Animals Antidiabetics Aortic valve Aortic Valve Stenosis - drug therapy Aortic Valve Stenosis - metabolism Arteriosclerosis Autophagy Calcification Calcification (ectopic) Cardiovascular diseases Cbfa-1 protein Cells, Cultured Core Binding Factor Alpha 1 Subunit - genetics Heart diseases Humanities and Social Sciences Hydroxychloroquine Immunoprecipitation Interstitial cells Metformin Metformin - pharmacology multidisciplinary Rats Rheumatic heart disease Science Science (multidisciplinary)
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Zusammenfassung:	Calcific aortic valve disease (CAVD) is the most common heart disease of the developed world. It has previously been established that metformin administration reduces arterial calcification via autophagy; however, whether metformin directly regulates CAVD has yet to be elucidated. In the present study we investigated whether metformin alleviates valvular calcification through the autophagy-mediated recycling of Runx2. Calcification was reduced in rat valve interstitial cells (RVICs) by metformin treatment (0.5–1.5 mM) ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-023-47774-6