Changing trends in serotypes of S. pneumoniae isolates causing invasive and non-invasive diseases in unvaccinated population in Mexico (2000-2014)

Highlights • We describe an annual decrease in the proportion of pneumococcal serotypes included in pneumococcal conjugate vaccines (PCV) causing invasive and non-invasive pneumococcal disease among people. • 5 years of age not targeted to receive the vaccine, after introduction of PCV in the universal vaccine program. • The strongest decrease of pneumococcal diseases was observed in the group of adults from 18 to 49 years of age. • A statistically significant increase of serotype 19A in all study groups was observed, except in adults ≥65 years. • A significant increase of non-vaccine pneumococcal serotypes was observed after the introduction of PCV: Serogroup 15 in the age group 50-64 years and serogroup 23 in children and adolescents among 5-17 years old.