PD-L1 Expression in Non-Small Cell Lung Cancer Specimens: Association with Clinicopathological Factors and Molecular Alterations

Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small cell lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022-05, Vol.23 (9), p.4517
Hauptverfasser:	Mansour, Mohammed S I, Malmros, Karina, Mager, Ulrich, Ericson Lindquist, Kajsa, Hejny, Kim, Holmgren, Benjamin, Seidal, Tomas, Dejmek, Annika, Dobra, Katalin, Planck, Maria, Brunnström, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis B7-H1 Antigen - metabolism Basic Medicine Biopsy Cancer and Oncology Cancer och onkologi Carcinoma, Non-Small-Cell Lung - pathology Cell and Molecular Biology Cell death Cell- och molekylärbiologi Cellular biology Clinical Medicine cytology EGFR Epidermal growth factor receptors ErbB Receptors - metabolism Growth patterns histology Humans Immune checkpoint inhibitors Immunohistochemistry Investigations Klinisk medicin KRAS Ligands Lung cancer Lung Neoplasms - pathology Medical and Health Sciences Medicin och hälsovetenskap Medicinska och farmaceutiska grundvetenskaper Metastasis mucinous Multivariate analysis Mutation Non-small cell lung carcinoma Paraffins PD-L1 protein Proto-Oncogene Proteins p21(ras) - genetics Proto-Oncogene Proteins p21(ras) - metabolism Retrospective Studies sample site Squamous cell carcinoma Tumors Variance analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Immune checkpoint inhibitors (ICI) targeting programmed cell death-1 or its ligand (PD-L1) have improved outcomes in non-small cell lung cancer (NSCLC). High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response. Following our previous investigation on PD-L1 in cytological samples, the aim of this study was to further explore the potential impacts of various clinicopathological and molecular factors on PD-L1 expression. Two retrospective NSCLC cohorts of 1131 and 651 specimens, respectively, were investigated for PD-L1 expression (
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23094517