Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines

Regioselective Suzuki-Miyaura reaction: application to the microwave-promoted synthesis of 4,7-diarylquinazolines

New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2010-05, Vol.15 (5), p.2949-2961
Hauptverfasser: Kabri, Youssef, Verhaeghe, Pierre, Gellis, Armand, Vanelle, Patrice
Format: Artikel
Sprache:eng
Schlagworte:
Carbon
Catalysis
Chemical Sciences
Microwaves
Organic Chemistry Phenomena
Pharmaceutical Preparations - chemical synthesis
quinazoline
Quinazolines - chemical synthesis
SRN1
Suzuki-Miyaura reaction
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Zusammenfassung:New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules15052949