RETROSPECTIVE ANALYSIS OF HISTOLOGIC ARCHIVE

Pre-clinical studies in Russia are required to be compliant with the Ministry of Health of Russia order N 708 «On approval of the rules of laboratory practice". One of the most important aspects of the quality of carried out research is possibility to reconstruct the study after its completion on the basis of archived materials. Order of Ministry of Health of Russia issued on 06.06.2013 N354n "On the procedure of autopsy" requires storage of biological materials in 10% formalin solution before the end of the histological study and also storage of micropreparations and paraffin blocks for3 years. Our study identifies and describes the most frequently encountered artificial changes that occur in the archived material with the passage of time in compliance with the recommendations on storage conditions.