INSTRUMENTAL AND MORPHOLOGICAL DIAGNOSTICS CRITERIA OF THE HERPES ZOSTER

Objective: To assess the instrumental and morphological diagnosis of herpes zoster (HZ). Methods: Instrumental and morphological diagnostics of HZ carried out in 40 patients. The spectra recorded on a standard two-beam IR spectrometer in the frequency range 4000-400 cm-1. Evaluate the results of pathomorphological studies, a computer-aided analysis system for microscopic images, consisting of a light-optical microscope used. Microscopic samples studied under the microscope Olympus CX21 at different magnifications with the Digital Microscope Camera MC-DO 48U (E). Results: Analysis of infrared spectra of blood plasma in HZ patients showed that when IR spectroscopic examination of blood of patients with different forms of HZ observed. A more significant shift of Vmax to the low-frequency region of the band 665 cm-1 observed a significant change in the IR absorption bands lying in the region frequencies of 1800-1200 cm-1, and very weak IR bands with Vmax 1450, 1300 and 1225 cm-1 completely smoothed out. Morphological examination of patients with different forms of HZ in the germ layer of the epidermis determines the phenomena of spongiosis and ballooning (vacuolar) dystrophy, caused by a sharp intracellular oedema and changes in the nuclei. Conclusion: The results of the research showed that both instrumental and morphological diagnostic methods for HZ are technically simple in execution, informative, economic and allow diagnosing all clinical forms of dermatosis in a short time. Keywords: Herpes zoster, instrumental and morphological diagnostics, IR spectrometry.