The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study

The Influence of Different Nonsteroidal Anti-Inflammatory Drugs on Alveolar Bone in Rats: An Experimental Study

The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication. Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I...

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Veröffentlicht in:Acta stomatologica croatica 2015-12, Vol.49 (4), p.325-330
Hauptverfasser: Hatipoglu, Mujgan Gungor, Inal, Sermet, Kabay, Sahin, Cayci, Muhammet Kasim, Deger, Ayşenur, Kuru, Halil Isa, Altikat, Sayit, Akkas, Gizem
Format: Artikel
Sprache:eng
Schlagworte:
Bone Remodeling
maxilla
Non-Steroidal Anti-Inflammatory Agents
Osteoblasts
Osteoclasts
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Zusammenfassung:The aim of this study was to investigate the effect of dexketoprofen trometamol, meloxicam, diclofenac sodium on any untreated alveolar bone when they are used as drugs for another indication. Twenty eight male Spraque-Dawley rats were randomized into four groups as dexketoprofen trometamol (Group I), meloxicam (Group II), diclofenac sodium (Group III) and control group. Nonsteroidal anti-inflammatory drugs (NSAID) were administered after a fibula fracture for 10 days. Untreated alveolar bone was histopathologically examined for spongious bone density, osteoclastic density and osteoblastic density. Spongious bone density was lower in study groups (Group I, group II and group III) than the control group (p
ISSN:0001-7019
1846-0410
DOI:10.15644/asc49/4/8