A Comparative Study of Fractional CO2 Laser versus Intradermal Injection of Autologous Platelet Rich Plasma in Melasma

Introduction: Melasma is a common acquired hyperpigmentation disorder of the face involving the cheeks, forehead, and commonly the upper lips. This condition is more common in women. The objective of this study was to compare the efficacy of fractional CO2 laser and intradermal platelet rich plasma (PRP) in melasma and to note down any 10.37821/ruhsjhs.4.2.2019.90-94 effects of fractional CO and autologous PRP in a prospective long 2 term follow up study. Methodology: A total of 60 patients with melasma attending the OPD of the Department of Dermatology were recruited. Half of study participants were treated with fractional CO laser treatments while the other half 2 were treated with intradermal autologous PRP once every two weeks for eight weeks. MASI score, visual analogue scale, objective and subjective assessment were done immediately before each session and two weeks after treatment. Results: The CO laser treatment created more variability 2 in MASI score due to effective treatment, while the PRP showed very little variability due to ineffective or less effective treatment results. Conclusion: Fractional CO laser is less invasive and 2 more effective as compared to intradermal injection of PRPin melasma patient.