Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac c...

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Veröffentlicht in:	Scientific reports 2021-11, Vol.11 (1), p.21865-21865, Article 21865
Hauptverfasser:	Takahashi, Hirotake, Kashiwagi, Yusuke, Nagoshi, Tomohisa, Tanaka, Yoshiro, Oi, Yuhei, Kimura, Haruka, Minai, Kousuke, Yoshimura, Michihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4019/592/75 692/4019/592/75/230 Aged Biomarkers - blood Body Mass Index Brain natriuretic peptide Catheterization Congestive heart failure Female Glomerular Filtration Rate Heart Disease Risk Factors Heart failure Heart Failure - blood Heart Failure - physiopathology Hemodynamics Hemoglobin Hemoglobins - metabolism Humanities and Social Sciences Humans Male Middle Aged Models, Cardiovascular multidisciplinary Multiple regression analysis Natriuretic Peptide, Brain - blood Peptides Regression Analysis Science Science (multidisciplinary) Stroke Volume Thyroid Thyroid hormones Triiodothyronine Triiodothyronine - blood Ventricle
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Zusammenfassung:	Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-01454-5