THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING

THE BNIP3 TRIAD: MITOCHONDRIA, LYSOSOMES AND INFLAMMATION IN HEALTHY MUSCLE AGING

During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-related sarcopenia. Here we studied the role of the mitophagy ada...

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Veröffentlicht in:Autophagy reports 2022-12, Vol.1 (1), p.252-255
Hauptverfasser: Irazoki, Andrea, Zorzano, Antonio, Sebastian, David
Format: Artikel
Sprache:eng
Schlagworte:
aging
inflammation
lysosome
mitochondria
mitophagy
muscle
sarcopenia
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Zusammenfassung:During aging, skeletal muscle undergoes a loss of mass, strength and function, encompassed in the biological process termed sarcopenia. Given demographic aging, it is essential to comprehend the molecular determinants resulting in age-related sarcopenia. Here we studied the role of the mitophagy adaptor BNIP3 in mitochondrial homeostasis and muscle during aging. Our findings reveal that BNIP3 orchestrates mitochondrial and lysosomal function to mitigate muscle inflammation and atrophy during aging.
ISSN:2769-4127
2769-4127
DOI:10.1080/27694127.2022.2082202