Editorial: Neuroimmune Interactions in Peripheral Neuropathy

[...]neuroimmune interactions represent an indispensable part of disease manifestations and may directly contribute to neural damage or repair processes (Kiefer et al., 2001; Said, 2007; Glass et al., 2010; Ransohoff, 2016). [...]exploring neuroimmune mechanisms of peripheral neuropathy has become an exciting frontier of the research field. In the Original Research article, Hu et al. exploited such advanced imaging power and reported the 3D anatomy of autonomic innervations in the mouse and human prostates for the first time. [...]the authors uncovered that loss of local sympathetic axons in the mouse prostate would cause the sterile inflammation mimicking the disease condition of chronic non-bacterial prostatitis/chronic pelvic pain syndrome. [...]immune responses, either locally or systemically, could impinge on the physiology and homeostasis of the nervous system. [...]it is essential to emphasize this bi-directional neuroimmune crosstalk in any disease context.