Leptin resistance in patients with nonalcoholic fatty liver disease associated with obesity and overweight

Aim: to study the association of the levels of leptin and its soluble receptor in blood serum with nonalcoholic fatty liver disease (NAFLD) in obese or overweight patients. Material and methods: the open study included 105 patients with obesity or excess body weight. Patients were examined for NAFLD and divided into two groups: the treatment group included patients with NAFLD (n = 77) and the control group included patients without NAFLD (n = 28). Results: complaints of pain in the right upper quadrant, hypertension and diabetes type 2, as well as waist circumference, body mass index, glucose and triglyceride levels were reported significantly more frequently in the group of patients with NAFLD. Leptin was positively and the level of its receptors was negatively correlated with the degree of weight gain. Between these parameters in the group of patients with obesity and excess body weight, an overall moderate negative correlation was reported (rs = (-0.370), p