VALUE OF A SCORING SYSTEM BASED ON INFLAMMATORY AND NUTRITIONAL INDICATORS IN PREDICTING THE EFFICACY OF NEOADJUVANT CHEMOTHERAPY FOR UPPER GASTRIC CANCER

Objective To investigate the association of inflammatory and nutritional indicators with the efficacy of neoadjuvant chemotherapy (NACT) in patients with upper gastric cancer before and after NACT, and to establish a clinical predictive model. Methods A total of 117 patients with upper gastric cancer who underwent NACT in Department of Gastroenterology in our hospital from April 2013 to January 2022 were enrolled, and according to the efficacy of chemotherapy, they were divided into effective group and ineffective group. Related clinical data were collected, such as age, sex, smoking history, drinking history, initial symptoms, tumor location, degree of tumor differentiation, tumor stage, tumor pathological type, and routine blood test results within one week before NACT and within one week after NACT. Univariate and multivariate analyses were performed to identify the influencing factors for the efficacy of NACT, and then a nomogram model was established and validated. Results The multivariate analysis showe