External Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil

We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous quality assurance is needed to adequately estimate...

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Veröffentlicht in:	Emerging infectious diseases 2018-05, Vol.24 (5), p.888-892
Hauptverfasser:	Fischer, Carlo, Pedroso, Celia, Mendrone, Jr, Alfredo, Bispo de Filippis, Ana Maria, Vallinoto, Antonio Carlos Rosário, Ribeiro, Bergmann Morais, Durigon, Edison Luiz, Marques, Jr, Ernesto T A, Campos, Gubio S, Viana, Isabelle F T, Levi, José Eduardo, Scarpelli, Luciano Cesar, Nogueira, Mauricio Lacerda, Bastos, Michele de Souza, Souza, Nathalia C Santiago, Khouri, Ricardo, Lira, Sanny, Komninakis, Shirley Vasconcelos, Baronti, Cécile, Charrel, Rémi N, Kümmerer, Beate M, Drosten, Christian, Brites, Carlos, de Lamballerie, Xavier, Niedrig, Matthias, Netto, Eduardo Martins, Drexler, Jan Felix
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Brazil Causes of diagnostics Dispatch External Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil Health aspects Humans Laboratories - standards Medical tests Molecular Diagnostic Techniques - standards Patient care Quality Control real-time RT-PCR RNA, Viral - isolation & purification Sensitivity and Specificity surveillance vector-borne infections Viral Load viruses Zika virus Zika Virus - isolation & purification
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Beschreibung
Zusammenfassung:	We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous quality assurance is needed to adequately estimate risk for Zika virus-associated disease and determine patient care.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2405.171747