Pulmonary Embolism and Increased Levels of d-Dimer in Patients with Coronavirus Disease

We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. These patients later showed development of persistent hypoxia with increased levels of d-dimer...

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Veröffentlicht in:	Emerging infectious diseases 2020-08, Vol.26 (8), p.1941-1943
Hauptverfasser:	Griffin, Daniel O, Jensen, Alexandra, Khan, Mushmoom, Chin, Jessica, Chin, Kelly, Saad, Jennifer, Parnell, Ryan, Awwad, Christopher, Patel, Darshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Antibodies, Monoclonal, Humanized - therapeutic use Anticoagulants - therapeutic use Betacoronavirus - drug effects Betacoronavirus - pathogenicity Betacoronavirus - physiology Biomarkers - blood Blood pressure Care and treatment Clinical Laboratory Techniques - methods Complications and side effects coronavirus disease Coronavirus Infections - complications Coronavirus Infections - diagnosis Coronavirus Infections - drug therapy Coronavirus Infections - virology Coronaviruses COVID-19 COVID-19 Testing Cytokine Release Syndrome - complications Cytokine Release Syndrome - diagnosis Cytokine Release Syndrome - drug therapy Cytokine Release Syndrome - virology Cytokine storm Enoxaparin - therapeutic use Expedited Female Fibrin Fibrinogen Degradation Products - metabolism Heart rate Hospitals Humans Hypotension Hypoxia - complications Hypoxia - diagnosis Hypoxia - drug therapy Hypoxia - virology Interleukins Male Methylprednisolone Hemisuccinate - therapeutic use Middle Aged Mortality Pandemics Patients Pneumonia, Viral - complications Pneumonia, Viral - diagnosis Pneumonia, Viral - drug therapy Pneumonia, Viral - virology Pulmonary embolism Pulmonary Embolism - complications Pulmonary Embolism - diagnosis Pulmonary Embolism - drug therapy Pulmonary Embolism - virology Pulmonary Embolism and Increased Levels of D-Dimer in Patients with Coronavirus Disease Pulmonary embolisms Research Letter respiratory infections Rivaroxaban Rivaroxaban - therapeutic use SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Thromboembolism Thrombosis Tomography, X-Ray Computed Treatment Outcome Type 2 diabetes viruses
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Zusammenfassung:	We report 3 patients with coronavirus disease who had a decline in respiratory status during their hospital course that responded well to intravenous steroids and interleukin-6 receptor antagonist therapy. These patients later showed development of persistent hypoxia with increased levels of d-dimer levels and were given a diagnosis of pulmonary embolisms.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2608.201477