Global genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae; A systematic review

•Prevalence of NDM-producing Klebsiella pneumoniae among clinical isolates worldwide.•Prevalence of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolated from clinical samples in different continents.•Distribution of NDM variants among NDM-producing Klebsiella pneumoniae from human clinical samples in different continents.•Distribution of sequence types (STs) among various New Delhi metallo-β-lactamase (NDM) variants in different continents.•Dissemination of different sequence types in NDM-producing Klebsiella pneumoniae isolated from clinical samples among different countries around the world. The global rise of antimicrobial resistance among bacterial strains is a rapidly growing challenge and is becoming a major public health concern. This study documents the worldwide spread and genotype distribution of human clinical isolates of New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae (NPKP). Several international databases, including Web of Science, Embase and Medline were searched (2010 - 2019) to identify studies addressing the frequency of NPKP regionally or worldwide. Of 4779 articles identified, 202 studies fulfilled the eligibility criteria and were included in our analysis. The frequency of NPKP in Asia, Europe, America, Africa and Oceania was 64.6%, 20.1%, 9.0%, 5.6% and 0.4%, respectively. The most prevalent sequence types (STs) among NPKP were ST11, ST290, ST147, ST340, ST15, ST278 and ST14 based on published studies. The dissemination of blaNDM variants in different STs among NPKP in the various region of world is a serious concern to public health. The prevalence of NPKP should be controlled by comprehensive infection control measures and optimization of antibiotic therapy.