Inconvenient relationship of haemoglobin A1c level with endothelial function in type 2 diabetes in a cross-sectional study

ObjectiveThe aim of this study was to determine the relationship of haemoglobin A1c (HbA1c) level with flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) in patients with type 2 diabetes.DesignCross-sectional study.Setting22 university hospitals and affiliated clinics in...

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Veröffentlicht in:	BMJ open 2021-06, Vol.11 (6), p.e045415-e045415
Hauptverfasser:	Yamaji, Takayuki, Harada, Takahiro, Hashimoto, Yu, Takaeko, Yuji, Kajikawa, Masato, Han, Yiming, Maruhashi, Tatsuya, Kishimoto, Shinji, Hashimoto, Haruki, Kihara, Yasuki, Hida, Eisuke, Chayama, Kazuaki, Goto, Chikara, Yusoff, Farina Mohamad, Nakashima, Ayumu, Higashi, Yukihito
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina pectoris Antidiabetics Antihypertensives Atherosclerosis Blood pressure Body mass index cardiology Cardiovascular disease Cerebrovascular disease Cholesterol Creatinine Cross-sectional studies Diabetes diabetes & endocrinology Diabetes and Endocrinology Drugs Endothelium general diabetes Glucose Heart attacks Heart rate Hemoglobin Hypertension Mortality Regression analysis Stroke Triglycerides Uric acid Variance analysis
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Zusammenfassung:	ObjectiveThe aim of this study was to determine the relationship of haemoglobin A1c (HbA1c) level with flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) in patients with type 2 diabetes.DesignCross-sectional study.Setting22 university hospitals and affiliated clinics in Japan.Participants1215 patients with type 2 diabetes including 349 patients not taking antidiabetic drugs.MeasuresWe evaluated FMD and HbA1c level. All patients were divided into four groups based on HbA1c level:
ISSN:	2044-6055 2044-6055
DOI:	10.1136/bmjopen-2020-045415