Clarithromycin monohydrate: a synchrotron X-ray powder study

Clarithromycin monohydrate: a synchrotron X-ray powder study

In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecu...

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Veröffentlicht in:Acta crystallographica. Section E, Structure reports online Structure reports online, 2012-03, Vol.68 (Pt 3), p.o667-o668
Hauptverfasser: Noguchi, Shuji, Fujiki, Sadahiro, Iwao, Yasunori, Miura, Keiko, Itai, Shigeru
Format: Artikel
Sprache:eng
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Organic Papers
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Zusammenfassung:In the crystal structure of the title compound, clarithromycin (CAM) monohydrate, C(38)H(69)NO(13)·H(2)O, the water mol-ecule behaves as a proton donor and is hydrogen bonded to the hy-droxy O atom of the CAM cladinose ring. The hy-droxy O atom also behaves as a proton donor, forming an inter-molecular hydrogen bond with one of the hy-droxy groups of the 14-membered aglycone ring. The CAM mol-ecules are linked through these hydrogen bonds into chains running parallel to the c axis.
ISSN:1600-5368
1600-5368
DOI:10.1107/S1600536812005090