Cannabinoid exposure and altered DNA methylation in rat and human sperm

Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite seque...

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Veröffentlicht in:	Epigenetics 2018-12, Vol.13 (12), p.1208-1221
Hauptverfasser:	Murphy, Susan K., Itchon-Ramos, Nilda, Visco, Zachary, Huang, Zhiqing, Grenier, Carole, Schrott, Rose, Acharya, Kelly, Boudreau, Marie-Helene, Price, Thomas M., Raburn, Douglas J., Corcoran, David L., Lucas, Joseph E., Mitchell, John T., McClernon, F. Joseph, Cauley, Marty, Hall, Brandon J., Levin, Edward D., Kollins, Scott H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Cannabinoid Receptor Agonists - pharmacology Cannabis CpG Islands DNA Methylation Dronabinol - pharmacology epigenetic reprogramming human Humans Male Marijuana Abuse - genetics rat Rats Rats, Sprague-Dawley Research Paper sperm Spermatozoa - drug effects Spermatozoa - metabolism tetrahydrocannabinol
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Zusammenfassung:	Little is known about the reproductive effects of paternal cannabis exposure. We evaluated associations between cannabis or tetrahydrocannabinol (THC) exposure and altered DNA methylation in sperm from humans and rats, respectively. DNA methylation, measured by reduced representation bisulfite sequencing, differed in the sperm of human users from non-users by at least 10% at 3,979 CpG sites. Pathway analyses indicated Hippo Signaling and Pathways in Cancer as enriched with altered genes (Bonferroni p
ISSN:	1559-2294 1559-2308
DOI:	10.1080/15592294.2018.1554521