Use of antimicrobial Dialkyl Carbamoyl Chloride (DACC) surface dressings for the treatment of infected post-surgical complications in neonates with low risk of adverse reactions: case series in the AOU Meyer NICU

The skin of the child presents significant differences compared to that of the adult; this diversity is even more marked if the skin of the newborn is taken into consideration. In fact, this is immature, as is its immune response. This results in weak responses to microorganisms. Therefore, the use of antibacterial dressings is necessary to manage the microbial load at the skin surface level. To this end, international consensus documents suggest that the use of products with a physical and mechanical action to remove bacteria is indicated. Bacterial uptake dressings that exploit DACC technology are bacteriostatic and non-bactericidal dressings; this "passive" control of the bacterial load avoids the rupture of the bacterial cell wall and the consequent release of endotoxins, which worsen the inflammatory state and prevent the healing of the lesion. Thanks to its purely physical principle, it also does not release any antimicrobial agent, which could create the risk of bacterial resistance and allergies. This treatment proposal aims to highlight the advantage and benefit of advanced dressings with DACC technology, for the prevention and treatment of pediatric and neonatal infected wounds.