High altitude retinopathy: An overview and new insights

High altitude retinopathy (HAR) is a common ocular disorder that occurs on ascent to high altitude. There are many clinical symptoms, retinal vascular dilatation, retinal edema and hemorrhage are common. These usually do not or slightly affect vision; rarely, severe cases develop serious or permanent vision loss. At present, the research progress of HAR mainly focuses on hemodynamic changes, blood-retinal barrier damage, oxidative stress and inflammatory response. Although the related studies on HAR are limited, it shows that HAR still belongs to hypoxia, and hypobaric hypoxia plays an aggravating role in promoting the development of the disease. Various studies have demonstrated the correlation of HAR with acute mountain sickness (AMS) and high-altitude cerebral edema (HACE), so a deeper understanding of HAR is important. The slow ascent rates and ascent altitude are the key to preventing any altitude sickness. Research on traditional chinese medicine (TCM) and western medicine has been gradually carried out. Further exploration of the pathogenesis and prevention strategies of HAR will provide better guidance for doctors and high-altitude travelers. •In recent years, high altitude retinopathy has become a hot issue, and how to prevent it needs to be paid more attention.•Studies have shown that high altitude retinopathy is related to acute mountain sickness and high altitude cerebral edema.•This paper discusses the role of changes in hemodynamics and blood-retinal barrier in high altitude retinopathy.•Finally, this paper puts forward a new direction and research idea for the future study of high altitude retinopathy.