Critical issues in periodontal regeneration

Periodontal disease is an inflammatory disease of the periodontium. It begins with the relatively benign gingivitis and becomes more established and destructive depending on the host, genetic, and environmental factors such as long-term plaque and calculus deposition. Subsequently, the connective tissue attachment to the root surface is lost causing bone resorption and formation of a periodontal pocket. We are in a new age of synthesis that demands vision, capabilities, logical reduction, and critical analysis for a constructive progress. In contrast to the conventional approaches of anti-inflammatory periodontal therapy, however, the regenerative procedures aimed at repairing lost periodontal tissues, including alveolar bone, periodontal ligament, and root cementum, remain more challenging and rapidly progressive periodontitis is attained.