Time‐dependent changes in plasma xanthine oxidoreductase during hospitalization of acute heart failure

Aims The aim of present study is to evaluate the clinical significance of the time‐dependent changes in xanthine oxidoreductase (XOR) activity during hospitalization for acute heart failure (AHF). Methods and results A total of 229 AHF patients who visited to emergency room were prospectively enroll...

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Veröffentlicht in:	ESC Heart Failure 2021-02, Vol.8 (1), p.595-604
Hauptverfasser:	Okazaki, Hirotake, Shirakabe, Akihiro, Matsushita, Masato, Shibata, Yusaku, Shigihara, Shota, Sawatani, Tomofumi, Tani, Kenichi, Kiuchi, Kazutaka, Otsuka, Yusuke, Murase, Takayo, Nakamura, Takashi, Kobayashi, Nobuaki, Hata, Noritake, Asai, Kuniya, Shimizu, Wataru
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute decompensated heart failure Blood pressure Cardiology Chromatography Creatinine Emergency medical care Heart failure Hospitalization Laboratories Mass spectrometry Original Original s Peptides Plasma Potassium Reactive oxygen species Scientific imaging Uric acid Vital signs XOR inhibitor
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Zusammenfassung:	Aims The aim of present study is to evaluate the clinical significance of the time‐dependent changes in xanthine oxidoreductase (XOR) activity during hospitalization for acute heart failure (AHF). Methods and results A total of 229 AHF patients who visited to emergency room were prospectively enrolled, and 187 patients were analysed. Blood samples were collected within 15 min of admission (Day 1), after 48–72 h (Day 3), and between Days 7 and 21 (Day 14). The AHF patients were divided into two groups according to the XOR activity on Day 1: the high‐XOR group (≥100 pmol/h/mL, n = 85) and the low‐XOR group (
ISSN:	2055-5822 2055-5822
DOI:	10.1002/ehf2.13129